Single-index models are becoming increasingly popular in many scientific applications as they offer the advantages of flexibility in regression modeling as well as interpretable covariate effects. In the context of survival analysis, the single-index hazards models are natural extensions of the Cox proportional hazards models. In this paper, we propose a novel estimation procedure for single-index hazard models under a monotone constraint of the index. We apply the profile likelihood method to obtain the semiparametric maximum likelihood estimator, where the novelty of the estimation procedure lies in estimating the unknown monotone link function by embedding the problem in isotonic regression with exponentially distributed random variables. The consistency of the proposed semiparametric maximum likelihood estimator is established under suitable regularity conditions. Numerical simulations are conducted to examine the finite-sample performance of the proposed method. An analysis of breast cancer data is presented for illustration.
Abstract: Suppose that an order restriction is imposed among several means in time series. We are interested in testing the homogeneity of these unknown means under this restriction. In the present paper, a test based on the isotonic regression is done for monotonic ordered means in time series with stationary process and short range dependent sequences errors. A test statistic is proposed using the penalized likelihood ratio (PLR) approach. Since the asymptotic null distribution of test statistic is complicated, its critical values are computed by using Monte Carlo simulation method for some values of sample sizes at different significance levels. The power study of our test statistic is provided which is more powerful than that of the test proposed by Brillinger (1989). Finally, to show the application of the proposed test, it is applied to real dataset contains monthly Iran rainfall records.