In this paper, we propose a new generalization of exponentiated modified Weibull distribution, called the McDonald exponentiated modified Weibull distribution. The new distribution has a large number of well-known lifetime special sub-models such as the McDonald exponentiated Weibull, beta exponentiated Weibull, exponentiated Weibull, exponentiated expo- nential, linear exponential distribution, generalized Rayleigh, among others. Some structural properties of the new distribution are studied. Moreover, we discuss the method of maximum likelihood for estimating the model parameters.