Journal of Data Science

Analyzing the gene-environment interaction (GEI) is crucial for understanding the etiology of many complex traits. Among various types of study designs, case-control studies are popular for analyzing gene-environment interactions due to their efficiency in collecting covariate information. Extensive literature explores efficient estimation under various assumptions made about the relationship between genetic and environmental variables. In this paper, we comprehensively review the methods based on or related to the retrospective likelihood, including the methods based on the hypothetical population concept, which has been largely overlooked in GEI research in the past decade. Furthermore, we establish the methodological connection between these two groups of methods by deriving a new estimator from both the retrospective likelihood and the hypothetical population perspectives. The validity of the derivation is demonstrated through numerical studies.

Imbalanced datasets present a significant challenge for machine learning models, often leading to biased predictions. To address this issue, data augmentation techniques are widely used to generate new samples for the minority class. However, in this paper, we challenge the common assumption that data augmentation is necessary to improve predictions on imbalanced datasets. Instead, we argue that adjusting the classifier cutoffs without data augmentation can produce similar results to oversampling techniques. Our study provides theoretical and empirical evidence to support this claim. Our findings contribute to a better understanding of the strengths and limitations of different approaches to dealing with imbalanced data, and help researchers and practitioners make informed decisions about which methods to use for a given task.

The assignment problem, crucial in various real-world applications, involves optimizing the allocation of agents to tasks for maximum utility. While it has been well-studied in the optimization literature when the underlying utilities between all agent-task pairs are known, research is sparse when the utilities are unknown and need to be learned from data on the fly. This paper addresses this gap, as motivated by mentor-mentee matching programs at many U.S. universities. We develop an efficient sequential assignment algorithm, with the aim of nearly maximizing the overall utility simultaneously over different time periods. Our proposed algorithm is to use stochastic bandit feedback to adaptively estimate the unknown utilities through linear regression models, integrating the Upper Confidence Bound (UCB) algorithm in the multi-armed bandit problem with the Hungarian algorithm in the assignment problem. We provide theoretical bounds of our algorithm for both the estimation error and the total regret. Additionally, numerical studies are also conducted to demonstrate the practical effectiveness of our algorithm.

Society’s capacity for algorithmic problem-solving has never been greater. Artificial Intelligence is now applied across more domains than ever, a consequence of powerful abstractions, abundant data, and accessible software. As capabilities have expanded, so have risks, with models often deployed without fully understanding their potential impacts. Interpretable and interactive machine learning aims to make complex models more transparent and controllable, enhancing user agency. This review synthesizes key principles from the growing literature in this field. We first introduce precise vocabulary for discussing interpretability, like the distinction between glass box and explainable models. We then explore connections to classical statistical and design principles, like parsimony and the gulfs of interaction. Basic explainability techniques – including learned embeddings, integrated gradients, and concept bottlenecks – are illustrated with a simple case study. We also review criteria for objectively evaluating interpretability approaches. Throughout, we underscore the importance of considering audience goals when designing interactive data-driven systems. Finally, we outline open challenges and discuss the potential role of data science in addressing them. Code to reproduce all examples can be found at https://go.wisc.edu/3k1ewe.