Journal of Data Science logo


Login Register

  1. Home
  2. Issues
  3. Volume 12, Issue 2 (2014)
  4. A comparison of individual patient analy ...

Journal of Data Science

Submit your article Information
  • Article info
  • More
    Article info

A comparison of individual patient analysis versus pooled study meta-analysis methodologies of exercise training trials in heart failure patients
Volume 12, Issue 2 (2014), pp. 377–384
Neil A. Smart   Michael Steele  

Authors

 
Placeholder
https://doi.org/10.6339/JDS.201404_12(2).0010
Pub. online: 4 August 2022      Type: Research Article      Open accessOpen Access

Published
4 August 2022

Abstract

Abstract: Background: A fixed effects meta-analysis of ten exercise training in trials heart failure patients was conducted. The aim of this current work was to compare different approaches to meta-analysis using the same dataset from the previous work on ten exercise training trials in heart failure patients. Methods: The following different meta-analysis techniques were used to analyse the data and compared the effects of exercise training on BNP, NT pro-BNP and peak VO2 before and after exercise training: (1) Trial level (traditional) level MA i) Follow up (post-exercise training intervention) outcome only. ii) Baseline-follow up difference (2) Patient level MA by Post-Stage ANCOVA i)naive model does not take into account trial level ii) Single Stage iii) Two Stage (3) Post outcome only i) Single stage ii) Pre-post outcome difference Single stage Results: The Individual patient data (IPD) analyses produced smaller effect sizes and 95% confidence intervals compared to conventional meta analysis. The advantage of the one-stage model is that it allows sub-group analyses, while the two-stage model is considered more robust but limited for sub-analyses. Conclusions: Our recommendation is to use one-stage or two-stage ANCOVA analysis, the former allows sub-group analysis, while the latter is considered to be more technically robust.

PDF XML
PDF XML

Copyright
No copyright data available.

Keywords
Individual patient data meta-analysis heart failure exercise training

Metrics
since February 2021
508

Article info
views

402

PDF
downloads

Export citation

Copy and paste formatted citation
Placeholder

Download citation in file


Share


RSS

Journal of data science

  • Online ISSN: 1683-8602
  • Print ISSN: 1680-743X

About

  • About journal

For contributors

  • Submit
  • OA Policy
  • Become a Peer-reviewer

Contact us

  • JDS@ruc.edu.cn
  • No. 59 Zhongguancun Street, Haidian District Beijing, 100872, P.R. China
Powered by PubliMill  •  Privacy policy