Abstract: The present article discusses and compares multiple testing procedures (MTPs) for controlling the family wise error rate. Machekano and Hubbard (2006) have proposed empirical Bayes approach that is a resampling based multiple testing procedure asymptotically controlling the familywise error rate. In this paper we provide some additional work on their procedure, and we develop resampling based step-down procedure asymptotically controlling the familywise error rate for testing the families of one-sided hypotheses. We apply these procedures for making successive comparisons between the treatment effects under a simple-order assumption. For example, the treatment means may be a sequences of increasing dose levels of a drug. Using simulations, we demonstrate that the proposed step-down procedure is less conservative than the Machekano and Hubbard’s procedure. The application of the procedure is illustrated with an example.
Abstract: The detection of slope change points in wind curves depends on linear curve-fitting. Hall and Titterington’s algorithm based on smoothing is adapted and compared to a Bayesian method of curve-fitting. After prior spline smoothing of the data, the algorithms are tested and the errors between the split-linear fitted wind and the real one are estimated. In our case, the adaptation of the edge-preserving smoothing algorithm gives the same good performance as automatic Bayesian curve-fitting based on a Monte Carlo Markov chain algorithm yet saves computation time.
Compositional data consist of known compositions vectors whose components are positive and defined in the interval (0,1) representing proportions or fractions of a “whole”. The sum of these components must be equal to one. Compositional data is present in different knowledge areas, as in geology, economy, medicine among many others. In this paper, we propose a new statistical tool for volleyball data, i.e., we introduce a Bayesian anal- ysis for compositional regression applying additive log-ratio (ALR) trans- formation and assuming uncorrelated and correlated errors. The Bayesian inference procedure based on Markov Chain Monte Carlo Methods (MCMC). The methodology is applied on an artificial and a real data set of volleyball.
The surrogate markers(SM) are the important factor for angiogenesis in cancer patients.In Metronomic Chemotherapy (MC) , physicians administer subtoxic doses of chemotherapy (without break) for long periods, to the target tumor angiogenesis. We propose a semiparametric approach, predictive risk modeling and time to control the level of surrogate marker to detect the perfect dose level of MC. It is based on the controlled level of surrogate marker, and the aim is to detect an Optimum Biological Dose (OBD) finding rather than a traditional Maximum Tolerated Dose (MTD) approach. The methods are illustrated with MC trial dataset to determine the best OBD and we investigate the performance of the model through simulation studies.
The COVID-19 pandemic has created a sudden need for a wider uptake of home-based telework as means of sustaining the production. Generally, teleworking arrangements impact directly worker’s efficiency and motivation. The direction of this impact, however, depends on the balance between positive effects of teleworking (e.g. increased flexibility and autonomy) and its downsides (e.g. blurring boundaries between private and work life). Moreover, these effects of teleworking can be amplified in case of vulnerable groups of workers, such as women. The first step in understanding the implications of teleworking on women is to have timely information on the extent of teleworking by age and gender. In the absence of timely official statistics, in this paper we propose a method for nowcasting the teleworking trends by age and gender for 20 Italian regions using mobile network operators (MNO) data. The method is developed and validated using MNO data together with the Italian quarterly Labour Force Survey. Our results confirm that the MNO data have the potential to be used as a tool for monitoring gender and age differences in teleworking patterns. This tool becomes even more important today as it could support the adequate gender mainstreaming in the ‘Next Generation EU’ recovery plan and help to manage related social impacts of COVID-19 through policymaking.