Journal of Data Science

Abstract: This paper considers the statistical problems of editing and imputing data of multiple time series generated by repetitive surveys. The case under study is that of the Survey of Cattle Slaughter in Mexico’s Municipal Abattoirs. The proposed procedure consists of two phases; firstly the data of each abattoir are edited to correct them for gross inconsistencies. Secondly, the missing data are imputed by means of restricted forecasting. This method uses all the historical and current information available for the abattoir, as well as multiple time series models from which efficient estimates of the missing data are obtained. Some empirical examples are shown to illustrate the usefulness of the method in practice.

Abstract: In this study, the data based on nucleic acid amplification tech niques (Polymerase chain reaction) consisting of 23 different transcript vari ables which are involved to investigate genetic mechanism regulating chlamy dial infection disease by measuring two different outcomes of muring C. pneumonia lung infection (disease expressed as lung weight increase and C. pneumonia load in the lung), have been analyzed. A model with fewer reduced transcript variables of interests at early infection stage has been obtained by using some of the traditional (stepwise regression, partial least squares regression (PLS)) and modern variable selection methods (least ab solute shrinkage and selection operator (LASSO), forward stagewise regres sion and least angle regression (LARS)). Through these variable selection methods, the variables of interest are selected to investigate the genetic mechanisms that determine the outcomes of chlamydial lung infection. The transcript variables Tim3, GATA3, Lacf, Arg2 (X4, X5, X8 and X13) are being detected as the main variables of interest to study the C. pneumonia disease (lung weight increase) or C. pneumonia lung load outcomes. Models including these key variables may provide possible answers to the problem of molecular mechanisms of chlamydial pathogenesis.

Abstract: Missing data are a common problem for researchers working with surveys and other types of questionnaires. Often, respondents do not respond to one or more items, making the conduct of statistical analyses, as well as the calculation of scores difficult. A number of methods have been developed for dealing with missing data, though most of these have focused on continuous variables. It is not clear that these techniques for imputation are appropriate for the categorical items that make up surveys. However, methods of imputation specifically designed for categorical data are either limited in terms of the number of variables they can accommodate, or have not been fully compared with the continuous data approaches used with categorical variables. The goal of the current study was to compare the performance of these explicitly categorical imputation approaches with the more well established continuous method used with categorical item responses. Results of the simulation study based on real data demonstrate that the continuous based imputation approach and a categorical method based on stochastic regression appear to perform well in terms of creating data that match the complete datasets in terms of logistic regression results.

Longitudinal data analysis had been widely developed in the past three decades. Longitudinal data are common in many fields such as public health, medicine, biological and social sciences. Longitudinal data have special nature as the individual may be observed during a long period of time. Hence, missing values are common in longitudinal data. The presence of missing values leads to biased results and complicates the analysis. The missing values have two patterns: intermittent and dropout. The missing data mechanisms are missing completely at random (MCAR), missing at random (MAR), and missing not at random (MNAR). The appropriate analysis relies heavily on the assumed mechanism and pattern. The parametric fractional imputation is developed to handle longitudinal data with intermittent missing pattern. The maximum likelihood estimates are obtained and the Jackkife method is used to obtain the standard errors of the parameters estimates. Finally a simulation study is conducted to validate the proposed approach. Also, the proposed approach is applied to a real data.

Subsampling the data is used in this paper as a learning method about the influence of the data points for drawing inference on the parameters of a fitted logistic regression model. The alternative, alternative regularized, alternative regularized lasso, and alternative regularized ridge estimators are proposed for the parameter estimation of logistic regression models and are then compared with the maximum likelihood estimators. The proposed alternative regularized estimators are obtained by using a tuning parameter but the proposed alternative estimators are not regularized. The proposed alternative regularized lasso estimators are the averaged standard lasso estimators and the alternative regularized ridge estimators are also the averaged standard ridge estimators over subsets of groups where the number of subsets could be smaller than the number of parameters. The values of the tuning parameters are obtained to make the alternative regularized estimators very close to the maximum likelihood estimators and the process is explained with two real data as well as a simulated study. The alternative and alternative regularized estimators always have the closed form expressions in terms of observations that the maximum likelihood estimators do not have. When the maximum likelihood estimators do not have the closed form expressions, the alternative regularized estimators thus obtained provide the approximate closed form expressions for them.