Journal of Data Science

Attention Deficit Hyperactivity Disorder (ADHD) is a frequent neurodevelopmental disorder in children that is commonly diagnosed subjectively. The objective detection of ADHD based on neuroimaging data has been a complex problem with low ranges of accuracy, possibly due to (among others) complex diagnostic processes, the high number of features considered and imperfect measurements in data collection. Hence, reliable neuroimaging biomarkers for detecting ADHD have been elusive. To address this problem we consider a recently proposed multi-model selection method called Sparse Wrapper AlGorithm (SWAG), which is a greedy algorithm that combines screening and wrapper approaches to create a set of low-dimensional models with good predictive power. While preserving the previous levels of accuracy, SWAG provides a measure of importance of brain regions for identifying ADHD. Our approach also provides a set of equally-performing and simple models which highlight the main feature combinations to be analyzed and the interactions between them. Taking advantage of the network of models resulting from this approach, we confirm the relevance of the frontal and temporal lobes as well as highlight how the different regions interact to detect the presence of ADHD. In particular, these results are fairly consistent across different learning mechanisms employed within the SWAG (i.e. logistic regression, linear and radial-kernel support vector machines) thereby providing population-level insights, as well as delivering feature combinations that are smaller and often perform better than those that would be used if employing their original versions directly.

We investigate how the use of bullet comparison algorithms and demonstrative evidence may affect juror perceptions of reliability, credibility, and understanding of expert witnesses and presented evidence. The use of statistical methods in forensic science is motivated by a lack of scientific validity and error rate issues present in many forensic analysis methods. We explore what our study says about how this type of forensic evidence is perceived in the courtroom – where individuals unfamiliar with advanced statistical methods are asked to evaluate results in order to assess guilt. In the course of our initial study, we found that individuals overwhelmingly provided high Likert scale ratings in reliability, credibility, and scientificity regardless of experimental condition. This discovery of scale compression - where responses are limited to a few values on a larger scale, despite experimental manipulations - limits statistical modeling but provides opportunities for new experimental manipulations which may improve future studies in this area.

By its nature, data science uses ideas and methodologies from computer science and statistics, along with field-specific knowledge, to describe, learn and predict. Recently, storytelling has been highlighted as an important extension of more traditional data science skills such as coding and modeling. Three courses in our new Master in Data Science and Analytic Storytelling program were designed to include interdisciplinary modules, mainly taught by faculty in storytelling-related disciplines, such as Communication and Art & Design. These courses were PDAT 622: Narrative, Argument, and Persuasion in Data Science; PDAT 624: Principles of Design in Data Visualization; and PDAT 625: Big Data Ethics and Security.

There has been remarkable progress in the field of deep learning, particularly in areas such as image classification, object detection, speech recognition, and natural language processing. Convolutional Neural Networks (CNNs) have emerged as a dominant model of computation in this domain, delivering exceptional accuracy in image recognition tasks. Inspired by their success, researchers have explored the application of CNNs to tabular data. However, CNNs trained on structured tabular data often yield subpar results. Hence, there has been a demonstrated gap between the performance of deep learning models and shallow models on tabular data. To that end, Tabular-to-Image (T2I) algorithms have been introduced to convert tabular data into an unstructured image format. T2I algorithms enable the encoding of spatial information into the image, which CNN models can effectively utilize for classification. In this work, we propose two novel T2I algorithms, Binary Image Encoding (BIE) and correlated Binary Image Encoding (cBIE), which preserve complex relationships in the generated image by leveraging the native binary representation of the data. Additionally, cBIE captures more spatial information by reordering columns based on their correlation to a feature. To evaluate the performance of our algorithms, we conducted experiments using four benchmark datasets, employing ResNet-50 as the deep learning model. Our results show that the ResNet-50 models trained with images generated using BIE and cBIE consistently outperformed or matched models trained on images created using the previous State of the Art method, Image Generator for Tabular Data (IGTD).

In randomized controlled trials, individual subjects experiencing recurrent events may display heterogeneous treatment effects. That is, certain subjects might experience beneficial effects, while others might observe negligible improvements or even encounter detrimental effects. To identify subgroups with heterogeneous treatment effects, an interaction survival tree approach is developed in this paper. The Classification and Regression Tree (CART) methodology (Breiman et al., 1984) is inherited to recursively partition the data into subsets that show the greatest interaction with the treatment. The heterogeneity of treatment effects is assessed through Cox’s proportional hazards model, with a frailty term to account for the correlation among recurrent events on each subject. A simulation study is conducted for evaluating the performance of the proposed method. Additionally, the method is applied to identify subgroups from a randomized, double-blind, placebo-controlled study for chronic granulomatous disease. R implementation code is publicly available on GitHub at the following URL: https://github.com/xgsu/IT-Frailty.

Brain imaging research poses challenges due to the intricate structure of the brain and the absence of clearly discernible features in the images. In this study, we propose a technique for analyzing brain image data identifying crucial regions relevant to patients’ conditions, specifically focusing on Diffusion Tensor Imaging data. Our method utilizes the Bayesian Dirichlet process prior incorporating generalized linear models, that enhances clustering performance while it benefits from the flexibility of accommodating varying numbers of clusters. Our approach improves the performance of identifying potential classes utilizing locational information by considering the proximity between locations as clustering constraints. We apply our technique to a dataset from Transforming Research and Clinical Knowledge in Traumatic Brain Injury study, aiming to identify important regions in the brain’s gray matter, white matter, and overall brain tissue that differentiate between young and old age groups. Additionally, we explore a link between our discoveries and the existing outcomes in the field of brain network research.

The use of visuals is a key component in scientific communication. Decisions about the design of a data visualization should be informed by what design elements best support the audience’s ability to perceive and understand the components of the data visualization. We build on the foundations of Cleveland and McGill’s work in graphical perception, employing a large, nationally-representative, probability-based panel of survey respondents to test perception in stacked bar charts. Our findings provide actionable guidance for data visualization practitioners to employ in their work.

Our contribution is to widen the scope of extreme value analysis applied to discrete-valued data. Extreme values of a random variable are commonly modeled using the generalized Pareto distribution, a peak-over-threshold method that often gives good results in practice. When data is discrete, we propose two other methods using a discrete generalized Pareto and a generalized Zipf distribution respectively. Both are theoretically motivated and we show that they perform well in estimating rare events in several simulated and real data cases such as word frequency, tornado outbreaks and multiple births.

One crucial aspect of precision medicine is to allow physicians to recommend the most suitable treatment for their patients. This requires understanding the treatment heterogeneity from a patient-centric view, quantified by estimating the individualized treatment effect (ITE). With a large amount of genetics data and medical factors being collected, a complete picture of individuals’ characteristics is forming, which provides more opportunities to accurately estimate ITE. Recent development using machine learning methods within the counterfactual outcome framework shows excellent potential in analyzing such data. In this research, we propose to extend meta-learning approaches to estimate individualized treatment effects with survival outcomes. Two meta-learning algorithms are considered, T-learner and X-learner, each combined with three types of machine learning methods: random survival forest, Bayesian accelerated failure time model and survival neural network. We examine the performance of the proposed methods and provide practical guidelines for their application in randomized clinical trials (RCTs). Moreover, we propose to use the Boruta algorithm to identify risk factors that contribute to treatment heterogeneity based on ITE estimates. The finite sample performances of these methods are compared through extensive simulations under different randomization designs. The proposed approach is applied to a large RCT of eye disease, namely, age-related macular degeneration (AMD), to estimate the ITE on delaying time-to-AMD progression and to make individualized treatment recommendations.

This study delves into the impact of the COVID-19 pandemic on the enrollment rates of on-site undergraduate programs within Brazilian public universities. Employing the Machine Learning Control Method, a counterfactual scenario was constructed in which the pandemic did not occur. By contrasting this hypothetical scenario with real-world data on new entrants, a variable was defined to characterize the impact of the COVID-19 pandemic on on-site undergraduate programs at Brazilian public universities. This variable reveals that the impact factor varies significantly when considering the geographical locations of the institutions offering these courses. Courses offered by institutions located in smaller population cities experienced a more pronounced impact compared to those situated in larger urban centers.