Journal of Data Science

Abstract: Information fusion has become a powerful tool for challenging applications such as biological prediction problems. In this paper, we apply a new information-theoretical fusion technique to HIV-1 protease cleavage site prediction, which is a problem that has been in the focus of much interest and investigation of the machine learning community recently. It poses a difficult classification task due to its high dimensional feature space and a relatively small set of available training patterns. We also apply a new set of biophysical features to this problem and present experiments with neural networks, support vector machines, and decision trees. Application of our feature set results in high recognition rates and concise decision trees, producing manageable rule sets that can guide future experiments. In particular, we found a combination of neural networks and support vector machines to be beneficial for this problem.

Abstract: We have developed an automated linking scheme for PUBMED citations with GO terms using SVM (Support Vector Machine), a classifica tion algorithm. The PUBMED database has been essential to life science re searchers with over 12 million citations. More recently GO (Gene Ontology) has provided a graph structure for biological process, cellular component, and molecular function of genomic data. By text mining the textual content of PUBMED and associating them with GO terms, we have built up an ontological map for these databases so that users can search PUBMED via GO terms and conversely GO entries via PUBMED classification. Conse quently, some interesting and unexpected knowledge may be captured from them for further data analysis and biological experimentation. This paper reports our results on SVM implementation and the need to parallelize for the training phase.