Abstract: This paper discusses a comprehensive statistical approach that will be useful in answering health-related questions concerning mortality and incidence rates of chronic diseases such as cancer and hypertension. The developed spatio-temporal models will be useful to explain the patterns of mortality rates of chronic disease in terms of environmental changes and social-economic conditions. In addition to age and time effects, models include two components of normally distributed residual effects and spatial effects, one to represent average regional effects and another to represent changes of subgroups within region over time. Numerical analysis is based on male lung cancer mortality data from the state of Missouri. Gibbs sampling is used to obtain the posterior quantities. As a result, all models discussed in this article fit well in stabilizing the mortality rates, especially in the less populated areas. Due to the richness of hierarchical settings, easy interpretation of parameters and ease of implementation, any models proposed in this paper can be applied generally to other sets of data.