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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JDS</journal-id>
      <journal-title-group>
        <journal-title>Journal of Data Science</journal-title>
      </journal-title-group>
      <issn pub-type="epub">1680-743X</issn>
      <issn pub-type="ppub">1680-743X</issn>
      <publisher>
        <publisher-name>SOSRUC</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">040306</article-id>
      <article-id pub-id-type="doi">10.6339/JDS.2006.04(3).284
</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Research Article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Developing Multivariate Survival Trees with a Proportional Hazards Structure</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Gao</surname>
            <given-names>Feng</given-names>
          </name>
          <xref ref-type="aff" rid="j_JDS_aff_000"/>
        </contrib>
        <aff id="j_JDS_aff_000">Washington University</aff>
        <contrib contrib-type="author">
          <name>
            <surname>Manatunga</surname>
            <given-names>Amita K.</given-names>
          </name>
          <xref ref-type="aff" rid="j_JDS_aff_001"/>
        </contrib>
        <aff id="j_JDS_aff_001">Emory University</aff>
        <contrib contrib-type="author">
          <name>
            <surname>Chen</surname>
            <given-names>Shande</given-names>
          </name>
          <xref ref-type="aff" rid="j_JDS_aff_002"/>
        </contrib>
        <aff id="j_JDS_aff_002">University of North Texas</aff>
      </contrib-group>
      <volume>4</volume>
      <issue>3</issue>
      <fpage>343</fpage>
      <lpage>356</lpage>
      <permissions>
        <ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/>
      </permissions>
      <abstract>
        <p>Abstract: In this paper, a tree-structured method is proposed to extend Classification and Regression Trees (CART) algorithm to multivariate survival data, assuming a proportional hazard structure in the whole tree. The method works on the marginal survivor distributions and uses a sandwich estimator of variance to account for the association between survival times. The Wald-test statistics is defined as the splitting rule and the survival trees are developed by maximizing between-node separation. The proposed method intends to classify patients into subgroups with distinctively different prognosis. However, unlike the conventional tree-growing algorithms which work on a subset of data at every partition, the proposed method deals with the whole data set and searches the global optimal split at each partition. The method is applied to a prostate cancer data and its performance is also evaluated by several simulation studies.</p>
      </abstract>
      <kwd-group>
        <label>Keywords</label>
        <kwd>CART</kwd>
        <kwd>multivariate survival data</kwd>
        <kwd>survival tree</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>
